Palladium‐Catalyzed Selective Carbonylation of (E)‐1,2‐Diidoalkenes

Abstract

A mild and selective palladium‐catalyzed carbonylation of (E)‐1,2‐diiodoalkenes protocol for the synthesis of (E)‐3‐iodoacrylate esters and maleic diesters has been developed. In the presence of PdCI₂, CuCl₂, and CO, (E)‐3‐iodoacrylate esters and maleic diesters were obtained selectively in moderate yields. Noteworthysis that a clean inversion of configuration takes place in the palladium‐catalyzed dicarbonylation of (E)‐1,2‐diiodoalkenes procedure.

Keywords:

• Carbonylation
• (E)‐1,2‐diiodoalkene
• (E)‐3‐iodoacrylate ester
• maleic diester
• palladium

Acknowledgments

We thank the National Natural Science Foundation of China (No. 20202002), Hunan Province Department of Education (No. 02C211), and Hunan Normal University for financial support.