![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
Synth. Commun. 2005, 35, 1
TITANIUM TETRAISOPROPOXIDE Catalyzed Synthesis of Base‐Sensitive Cyanoguanidine Analogs
John K. Lynch, Peggy Huang, and Hao Bai
Neurological and Urological Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, USA
The synthesis of base‐sensitive cyanoguanidine analogs of potent potassium channel openers was accomplished in two steps by converting the thiourea to a carbodiimide followed by Ti(OiPr)4 catalyzed addition of cyanamide in dichloromethane.
Abstract
Synth. Commun. 2005, 35, 9
An Unusual Copper Catalyzed Iodine Mediated Aziridination of Olefins with the Direct Use of p‐Toluenesulphonamide
Suman L. Jain, Vishal B. Sharma, and Bir Sain
Chemical and Biosciences Division Indian Institute of Petroleum, Dehradun, India
p‐Toluenesulphonamide/I2 was found to be an efficient system for the copper catalyzed aziridination of olefins in good yields under very mild conditions.
Abstract
Synth. Commun. 2005, 35, 15
A Simple Regioselective demethylation of p‐Aryl Methyl Ethers Using Aluminium Chloride‐Dichloromethane System
Arvind S. Negi, Sunil K. Chattopadhyay, Sachin Srivastava, and Asish K. Bhattacharya
Phytochemistry Division, Central Institute of Medicinal and Aromatic Plants, Lucknow, India.
Abstract
Synth. Commun. 2005, 35, 23
A Rapid, Mild, Efficient, and Solvent‐Free Friedel‐Crafts Acylation of N‐Acetyltetrahydroharmine
Sabira Begum, Syed Imran Hassan, and Bina S. Siddiqui
H. E. J. Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi, Pakistan
The first solid‐phase, rapid, and mild synthesis of 10‐acyl and 12‐acyl analogues of N‐acetyltetrahydroharmine by Friedel‐Crafts acylation has been developed.
Abstract
Synth. Commun. 2005, 35, 41
An Efficient Synthesis of Double 2‐Alkylthio‐5‐phenylmethylidene‐4H‐imidazol‐4‐ones
Yong Sun
Department of Chemistry, Yunyang Teachers College, Danjiangkou, P. R. China
Ming‐Wu Ding
Institute of Organic Synthesis, College of Chemistry, Central China Normal University, Wuhan, P. R. China
Abstract
Synth. Commun. 2005, 35, 49
A Convenient Synthetic Route to 2,5‐DialkoxyterephthAlaldehyde
Pin Shao, Zhen Li, Jianlin Luo, Hongli Wang, and Jingui Qin
Department of Chemistry, Wuhan University, Wuhan, P. R. China
A convenient method for synthesizing 2,5‐dialkoxyterephthalaldehyde by oxidation of 1,4‐dialkoxy‐2,5‐bis(halogenomethyl)benzene with dimethyl sulfoxide in one step is described.
Abstract
Synth. Commun. 2005, 35, 55
Synthetic Study of Substituted Arylsulfonylphenylbenzamides
Denghuang Gong1, Jinfeng Li1, Chengye Yuan1, and Junying Yuan2
1Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
2Department of Cell Biology, Harvard Medical School, Boston, MA, USA
For the structure‐activity relationship, a series of substituted arylsulfonylphenylbenzamides is reported.
Abstract
Synth. Commun. 2005, 35, 67
Microwave‐Assisted Synthesis of N‐Hydroxyphthalimide Derivatives
Kazuhiro Sugamoto, Yoh‐ichi Matsushita, Yu‐hei Kameda, Masahiko Suzuki, and Takanao Matsui
Faculty of Engineering, University of Miyazaki, Miyazaki, Japan
N‐Hydroxyphthalimide derivatives are readily obtained in good yields by the reaction of phthalic anhydrides with hydroxylamine hydrochloride in the presence of pyridine under microwave irradiation.
Abstract
Synth. Commun. 2005, 35, 71
A Convenient Strategy for the Total Synthesis of Pisiferic Acid Type Diterpenes
Hui Zhu and Pengfei Tu
School of Pharmaceutical Sciences, Health Science Center of Peking University, Beijing, China
A practical method for the total synthesis of pisiferic acid type diterpenoids is described. This involves Robinson annulation of the keto ester for the key intermediate.
Abstract
Synth. Commun. 2005, 35, 79
Solvent‐Free Microwave Michael Addition Between EMME and Various Nucleophiles
André Loupy,1 Suk Jin Song,2 Seong Jin Cho,2, Dong Kyu Park,2 and Tae Woo Kwon2
1Laboratoire des Réactions Sélectives sur Supports, associé au CNRS, UMR 8615‐ICMMO, Université Paris‐Sud, Batiment 410, F‐91405 Orsay Cédex, France
2College of Science, Kyungsung University, Busan, Korea
Michael addition reaction between EMME and various O, S, N nucleophiles were investigated in the presence of catalysts such as KF, KOH, or K(OCCH3)3 under solvent‐free conditions either neat or on alumina as solid support. Compared to low reactivity of alcohols (40 to 80% yields according to aliphatic chain), aniline or thiophenol gave good to excellent yields (90–99%).
Abstract
Synth. Commun. 2005, 35, 89
Microwave‐promoted one‐pot three‐component reaction to [60]Fulleropyrrolidine Derivatives
Jianming Zhang,1 Wen Yang,1 Sheng Wang1, Ping He,2 and Shizheng Zhu2
1Department of Chemistry, School of Science, Shanghai University, Shanghai, China
2Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai, China
Under microwave irradiation and solvent‐free condition, one‐pot three‐component reaction of C60, amino acid and aldehyde gave the corresponding [60]fulleropyrrolidine derivatives via dipolar [2 + 3] cycloaddition in moderate to good yields. Compared to the conventional thermal heating method, it provides a convenient and expeditious route to N‐unsubstituted fulleropyrrolidines 3.
Abstract
Synth. Commun. 2005, 35, 97
A Clean Synthesis of 1‐Oxo‐hexahydroxanthene Derivatives in Aqueous Media Catalyzed by TEBA
Xiang‐shan Wang,1,2,3 Da‐qing Shi,1,3 Yu‐ling Li,1,3 Hong Chen,2 Xian‐yong Wei,2 and Zhi‐min Zong2
1Department of Chemistry, Xuzhou Normal University, Xuzhou, Jiangsu, China
2School of Chemical Engineering, China University of Mining of Technology, Xuzhou, China
3The Key Laboratory of Biotechnology on Medical Plant, Xuzhou, China
A series of 1‐oxo‐1,2,3,4,9,10‐hexahydroxanthene derivatives were synthesized from substituted salicylaldehydes and substituted 1,3‐hexanedione in water at 90°C catalyzed by TEBA. The structure of the product was confirmed by X‐ray analysis.
Abstract
Synth. Commun. 2005, 35, 105
Palladium‐Catalyzed selective carbonylation of (E)‐1,2‐Diidoalkenes
Jin‐Heng Li and Shi Tang
Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, China
Abstract
Synth. Commun. 2005, 35, 115
Synthesis of Monodisperse Oligo[(1,4‐phenyleneethynylene)‐alt‐(2,5‐thiopheneethynylene)]s
Guorong Li, Xianhong Wang, Ji Li, Xiaojiang Zhao, and Fosong Wang
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Changchun, China
Synthesis of monodisperse oligo[(1,4‐phenyleneethynylene)‐alt‐(2,5‐thiopheneethynylene)]s using an iterative divergent/convergent doubling strategy was presented.
Abstract
Synth. Commun. 2005, 35, 121
The N,N,N′,N′–Tetramethylethylenediamine Mediated Baylis‐Hillman Reaction
Sanhu Zhao and Zhaobin Chen
School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, P.R. China
The Baylis‐Hillman reaction of aromatic aldehydes with various activated alkenes catalyzed by N,N,N′,N′–Tetramethylethylenediamine (TMEDA) in aqueous medium were reported. The efficiency of this catalyst was examined in comparison with DABCO. It was demonstrated that this amine is not only a very efficient catalyst for the Baylis‐Hillman reaction, it also outperforms the most widely used catalyst DABCO.
Abstract
Synth. Commun. 2005, 35, 129
Synthesis and Structure of a Novel Disulfide‐Containing Aniline
Shi‐Ren Deng,1 Lei Wu,1 Hao Wang,1 Bin Zhou,1 Wai‐Kwok Wong,2 Jian‐ping Guo,2 Zao‐Ying Li,1 and Yun‐Hong Zhou,1
1Department of Chemistry, Wuhan University, Wuhan, P. R. China
2Department of Chemistry, Hong Kong Baptist University, Hong Kong, P. R. China
Abstract
Synth. Commun. 2005, 35, 137
A Clean and Simple Synthesis of 6‐Amino‐4‐Aryl‐5‐Cyano‐3‐Methyl‐1‐Phenyl‐1, 4‐Dihydropyrano[2,3‐c] Pyrazole in Water
Tong‐Shou Jin, Ai‐Qing Wang, Zhao‐Li Cheng, Jian‐She Zhang, and Tong‐Shuang Li
Department of Chemistry, College of Chemistry and Environmental Science, Hebei University, Baoding, P. R. China
A simple and clean method for producing 6‐amino‐4‐aryl‐5‐cyano‐3‐methyl‐1‐phenyl‐1,4‐ dihydropyrano[2,3‐c]pyrazole in water is described. This method provides several advantages such as mild reaction conditions, simple work‐up procedure, and being environmentally friendly.
Abstract
Synth. Commun. 2005, 35, 145
A Simple and Effective Method for Chemoselective Esterification of Phenolic Acids
Wei Guo, Junfei Li, Ningjuan Fan, Weiwei Wu, Peiwen Zhou, and Chizhong Xia
School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, China
A new method for efficient and chemoselective esterification of phenolic acids in KHCO3/alkyl halide/DMF reaction system is described, by which a series of phenoic acid esters were obtained in excellent yields.
Abstract
Synth. Commun. 2005, 35, 153
Cycloisomerization of Olefinic Carboxylic Acids Catalyzed by Trifluoromethanesulfonic Acid
Lydie Coulombel1 and Elisabet Duñach1,2
1Laboratoire Arômes, Synthèses et Interactions
2Laboratoire de Chimie Bio‐Organique, UMR CNRS 6001 Université de Nice‐Sophia Antipolis, Parc Valrose, Nice cedex 2, France
