A Practical Synthesis of 3,3‐Difluorocyclobutane Carboxylic Acid

Abstract

We reported a straightforward, three step synthesis of 3,3‐difluorocyclobutane carboxylic acid.

Keywords:

• 3,3‐Difluorocyclobutane carboxylic acid
• synthesis
• lipophilicity

Notes

¹The material safety data sheet lists the following hazards: highly flammable, very toxic (EU definition), may cause cancer, causes burns, severe irritant.

²This paper reports the same transformation may be achieved using sulfur tetrafluoride, but the yield was not reported.

³After 2 days at room temperature an approximately 70:30 mixture of 1 and 10 was formed.