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Abstract
Synth. Commun. 2005, 35, 631
A Versatile One‐Pot Synthesis of Dialkyl Disulfides and Sulfides
David W. Emerson, Byron L. Bennett, and Spencer M. Steinberg
Department of Chemistry, University of Nevada, Las Vegas, Nevada, USA
1‐Bromo‐3‐fluoropropane reacted with thiourea to form an S‐alkyl‐thiuroium bromide. Addition of sodium hydroxide and hydrogen peroxide in situ yielded 3‐fluoro‐1‐propyl disulfide in 58% yield.
Abstract
Synth. Commun. 2005, 35, 639
Routes to Sydnone‐containing Oligomeric Areneynes
Andrew J. Weisner,1 Thomas M. Cooper,2 and Kenneth Turnbull1
1Chemistry Department, Wright State University, Dayton, Ohio, USA
2Materials and Manufacturing Directorate, Air Force Research Laboratory, Ohio, USA
Abstract
Synth. Commun. 2005, 35, 653
RuCl3 catalyzed one‐pot synthesis of α‐aminonitriles
Surya Kanta De
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
Abstract
Synth. Commun. 2005, 35, 657
A Practical Synthesis of 3,3‐Difluorocyclobutane Carboxylic Acid
Dirk Elend, David Fengas, and M. Jonathan Fray
Discovery Chemistry Department, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
We report a straightforward, three step synthesis of 3,3‐difluorocyclobutane carboxylic acid.
Abstract
Synth. Commun. 2005, 35, 663
Modification of the Titanium(IV) Isopropoxide Reductive Amination Reaction: Application to Solid Phase Synthesis
John C. DiCesare, Celesta E. White, Wendy E. Rasmussen, Bryan M. White, Charles B. McComas, and Laura E. Craft
Department of Chemistry and Biochemistry, The University of Tulsa, Tulsa, OK 74104, USA
Secondary amines are synthesized by a modification of the titanium(IV) isopropoxide reductive amination reaction. The modified procedure has been utilized for both solution and solid phase synthesis with excellent purity and yields.
Abstract
Synth. Commun. 2005, 35, 669
Phase‐Transfer Catalyzed Pseudohalogenation of Phosphorochloridates
E. Shi and C. Pei
Beijing Institute of Pharmaceutical Chemistry, Beijing, P. R. China
Synthesis of phosphorazidates phosphorocyanidates, and phosphor(isothiocyanidate)s from pseudohalogenation of phosphorochloridates by sodium pseudohalides under two kinds of mild phase‐transfer catalyzed conditions is described.
Abstract
Synth. Commun. 2005, 35, 675
Microwave‐Assisted Facile Synthesis of Dispiro 4‐Imino‐1,3‐Dioxolanes
Mohammad Bagher Teimouri
Gas Conversion Department, Iran Polymer and Petrochemical Institute, Tehran, Iran
Abstract
Synth. Commun. 2005, 35, 683
Synthesis of New 9‐(N‐SUBSTITUTED)‐Acridinamines Bearing A Pendant Polymerizable Side Chain
Gabriel Roubaud, Sebastien Billeau, Robert Faure, Maxime Robin, and Jean‐Pierre Galy
UMR CNRS 6178 Symbio, Laboratoire de Valorisation de la Chimie Fine, Faculté des Sciences et Techniques de Saint Jérôme, Université Paul Cézanne, Av. Escadrille Normandie‐Niemen, 13397 Marseille Cedex 3, France
New 9‐(N‐substituted)‐acridinamines (7–11), have been synthesized from allyl 4‐(9‐chloro‐7‐methoxy‐2‐acridinyl)‐butanoate (6).
Abstract
Synth. Commun. 2005, 35, 693
An Easy Access to Variously Substituted Pyrroles Starting From Ketene Dithioacetals
Geoffroy L. Sommen,1 Alain Comel,2 and Gilbert Kirsch2
1Organisch‐Chemisches Institut der Universität Zürich, Zürich, Switzerland
2Laboratoire d'Ingénierie Moléculaire et Biochimie Pharmacologique, Faculté des Sciences, Université de Metz, Metz, France
Variously substituted pyrroles can easily be synthesized in two steps by reacting a primary or secondary amine and a ketene dithioacetal in a basic medium in moderate to good yield. Ketene dithioacetals are readily prepared from acetylaceton or malononitrile, carbon disulfide, and methyl iodide.
Abstract
Synth. Commun. 2005, 35, 701
Synthesis and Characterization of Thienorphine and its Glucuronide Conjugate
Chun‐He Liu, He Liu, Xiang‐Yu Han, Bo Wu, Bo‐Hua Zhong, and Ze‐Hui Gong
Beijing Institute of Pharmacology and Toxicology Academy, Beijing 100850, P. R. China
A potent mixed agonist and antagonist opiate receptor thienorphine and its glucuronide conjugate were synthesized. The structure of thienorphine was determined by X‐ray crystallography.
Abstract
Synth. Commun. 2005, 35, 711
Anodic Cyanation of (−)‐N‐Phenyl‐2‐Methylpiperidine: A Short Synthesis of (+)‐Solenopsin A and (+)‐Isosolenopsin A
Nicolas Girard,1 Jean‐Pierre Hurvois,1 Loic Toupet,2 and Claude Moinet1
1Laboratoire d'électrochimie, UMR 6509, Institut de Chimie, Université de Rennes I, Campus de Beaulieu, F‐35042 Rennes Cedex, France
2Groupe Matière Condensée et Matériaux, Université de Rennes I, Campus de Beaulieu, F‐35042 Rennes Cedex, France
Abstract
Synth. Commun. 2005, 35, 725
A Convenient Synthesis of 1‐Amino‐7‐(Piperidin‐4‐YL)Isoquinoline
Sergey Shkavrov, Sergey Popov, Dmitry Kravchenko, and Mikhail Krasavin
Chemical Diversity Research Institute, Khimki, Moscow Reg., 114401, Russia
An optimized synthesis of 2‐amino‐7‐(piperidin‐4‐yl)isoquinoline, starting from 4‐bromocinnamic acid, has been developed.
Abstract
Synth. Commun. 2005, 35, 731
Convenient Preparation of O‐Alkylhydroxamic Acids Using 2‐Acyl‐pyridazin‐3(2H)‐ones
Jeum‐Jong Kim,1 Young‐Dae Park,1 Ho‐Kyun Kim,1 Su‐Dong Cho,1 Ju‐Kyeong Kim,1 Sang‐Gyeong Lee,2 and Yong‐Jin Yoon1
1Department of Chemistry and Environmental Biotechnology National Core Research Center, Gyeongsang National University, Chinju, Korea
2Department of Chemistry and Research Institute of Life Science, Gyeongsang National University, Chinju, Korea
Abstract
Synth. Commun. 2005, 35, 739
Organic Reactions in Ionic Liquids: Ionic Liquids Ethylammonium Nitrate Promoted Knoevenagel Condensation of Aromatic Aldehydes with Active Methylene Compounds
Yi Hu,1,2 Jue Chen,1,2 Zhang‐Gao Le,1,2,3 and Qin‐Guo Zheng4
1Ningbo Institute of Technology, Zhejiang University, Ningbo, P. R. China
2Department of Chemistry, Zhejiang University (Xi Xi Campus), Hangzhou, P. R.China
3Department of Applied Chemistry, East China Institute of Technology, Fuzhou, P. R.China
4Pharmaceutical Science Research Institute, Aston University, Aston Triangle, Birmingham, UK
Abstract
Synth. Commun. 2005, 35, 745
Efficient Synthesis of γ‐Keto Esters from Enamines and EDA
Dan Huang,1,2 Ming Yan,1 Wei‐Jie Zhao,1 and Qi Shen1
1Department of Chemistry and Chemical Engineering, Suzhou University, Suzhou, Jiangsu, China
2Department of Chemistry, Nantong Teachers College, Nantong, Jiangsu, China
The reaction of enamines with ethyl diazoacetate (EDA) catalyzed by dirhodium and copper complexes provided γ‐keto esters in good yields.
Abstract
Synth. Commun. 2005, 35, 751
Asymmetric Cyanohydrin Synthesis Catalyzed by Mn(salen) Complex/Triphenylphosphine Oxide
Sung Soo Kim and Sang Hyuck Lee
Department of Chemistry and Center for Chemical Dynamics, Inha University, Incheon, South Korea
Various aldehydes have undergone asymmetrical trimethylsilylcyanation (TMSCN) with (CH3)3SiCN. The yield is over 90% in most cases and ee's range from 44% to 64% employing chiral Mn(salen) and triphenylphosphine oxide as the catalyst.
Abstract
Synth. Commun. 2005, 35, 761
Synthesis of Aromatic Thioamide from Nitrile without Handling of Gaseous Hydrogen Sulfide
Akira Manaka and Masakazu Sato
Medicinal Chemistry Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1‐403, Yoshino‐cho, Kita‐ku, Saitama, Japan
