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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 35, 2005 - Issue 6
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Original Articles

Microwave‐Assisted Generation and Reactions of Nitrile Sulfides

Angus J. Morrison Organon Research, Newhouse, Lanarkshire, U.K.
,
R. Michael Paton School of Chemistry, University of Edinburgh, Edinburgh, Scotland, UKCorrespondence[email protected]
&
Robert D. Sharp School of Chemistry, University of Edinburgh, Edinburgh, Scotland, UK
Pages 807-813 | Published online: 20 Aug 2006
 
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Abstract

An improved practical method is described for the generation of benzonitrile sulfide based on microwave‐assisted decarboxylation of 5‐phenyl‐1,3,4‐oxathiazol‐2‐one. Reaction times for the preparation of cycloadducts (e.g. isothiazoles and 1,2,4‐thiadiazoles) derived from the nitrile sulphide are reduced from typically 15–30 h to approximately 15 min.

Acknowledgment

We thank the EPSRC and Organon Research for financial support.

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Related Research Data

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