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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 35, 2005 - Issue 6
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Original Articles

Chemoselective Reduction of Aldehydes in the Presence of Ketones with NaBH4 in Polyethylene Glycol Dimethyl Ethers

Kiyoshi Tanemura School of Dentistry at Niigata, The Nippon Dental University, Hamaura‐cho, Niigata, JapanCorrespondence[email protected]
,
Tsuneo Suzuki School of Dentistry at Niigata, The Nippon Dental University, Hamaura‐cho, Niigata, Japan
,
Yoko Nishida School of Dentistry at Niigata, The Nippon Dental University, Hamaura‐cho, Niigata, Japan
,
Koko Satsumabayashi School of Dentistry at Niigata, The Nippon Dental University, Hamaura‐cho, Niigata, Japan
&
Takaaki Horaguchi Department of Chemistry, Faculty of Science, Niigata University, Ikarashi, Niigata, Japan
Pages 867-872 | Received 20 Oct 2004, Published online: 20 Aug 2006
 
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Abstract

Aldehydes and ketones were treated with NaBH4 in polyethylene glycol dimethyl ethers (PEGDME) to give the corresponding alcohols in good yields. Chemoselective reduction of aldehydes in the presence of ketones was described.

Acknowledgments

We are grateful for the financial support from The Nippon Dental University, Niigata, Japan.

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