Fe‐HCl: An Efficient Reagent for Deprotection of Oximes as well as Selective Oxidative Hydrolysis of Nitroalkenes and Nitroalkanes to Ketones

Abstract

Fe‐HCl mixture was found to selectively perform oxidative hydrolysis of the nitroalkenes 1a–j and nitroalkanes 2a–j to the ketones 3a–j. Also, the reagent was observed to deprotect the oximes 7a–j to carbonyl compounds 8a–j in excellent yields.

Keywords:

• Deprotection of oximes
• Fe
• HCl
• hydrolysis
• ketones
• nitroalkanes
• nitroalkenes
• oxidation

Acknowledgment

S. D. thanks University Grants Commission, New Delhi, India, for Junior Research Fellowship and the other authors thank Council of Scientific and Industrial Research, New Delhi, India, for the generous grant.