Benzoyl Cyanide: A Mild and Efficient Reagent for Benzoylation of Nucleosides

Ashok K. Prasad Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, IndiaCorrespondence[email protected]

Vineet Kumar Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, India

Jyotirmoy Maity Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, India

Zhiwei Wang ISIS Pharmaceuticals Inc., Carlsbad, California, USA

Vasulinga T. Ravikumar ISIS Pharmaceuticals Inc., Carlsbad, California, USA

Yogesh S. Sanghvi ISIS Pharmaceuticals Inc., Carlsbad, California, USA; Rasayan Inc., 2802 Crystal Ridge Road, Encinitas, CA, 92024, USA

Virinder S. Parmar Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, India

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Abstract

Efficient benzoylation of various nucleosides has been accomplished in pyridine with a catalytic amount of DMAP and benzoyl cyanide under mild conditions.

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Acknowledgment

This project was funded by ISIS pharmaceuticals Inc., California, U.S.A. V. K. and J. M. thank the Council of Scientific and Industrial Research (New Delhi, India) for the award of Junior Research Fellowships.

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Benzoyl Cyanide: A Mild and Efficient Reagent for Benzoylation of Nucleosides

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Benzoyl Cyanide: A Mild and Efficient Reagent for Benzoylation of Nucleosides

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