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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 35, 2005 - Issue 7
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Original Articles

Syntheses of 4‐[(1H,3H)‐Pyrimidine‐2,4‐Dion‐1‐yl]‐ and 4‐[(1H,3H)‐5‐Methylpyrimidine‐2,4‐Dion‐1‐yl]‐1,6‐Heptadienes

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Pages 1003-1010 | Received 09 Dec 2004, Published online: 21 Aug 2006
 

Abstract

Heptadienes containing nucleic bases are attractive building blocks for the synthesis of carbocyclic oligonucleotide analogs. Herein, we report an alternative synthetic route to 4‐[(1H,3H)‐pyrimidine‐2,4‐dion‐1‐yl]‐1,6‐heptadiene and 4‐[(1H,3H)‐5‐methylpyrimidine‐2,4‐dion‐1‐yl]‐1,6‐heptadiene via building the pyrimidine ring utilizing 4‐isocyanato‐1,6‐heptadiene intermediate.

Acknowledgments

The authors are grateful to the Lebanese National Council for Scientific Research (LNCSR) for partial financial support of this research project.

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