Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 35, 2005 - Issue 8
50
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Synthesis of 1‐[(2‐Hydroxyethoxy)Methyl]‐6‐(5,6,7,8‐Tetrahydronaphthylmethyl‐1)Thymine as Novel Inhibitor against Drug‐Resistant HIV Mutants

, , &
Pages 1095-1102 | Received 04 Oct 2002, Published online: 16 Aug 2006
 

Abstract

Synthesis of two new 1‐[(2‐hydroxyethoxy)methyl]‐6‐(5,6,7,8‐tetrahydronaphthylmethyl‐1)thymine derivatives 10ab, as potent inhibitors against a mutant type of HIV, starting from thymine, is described. In the preparation of the corresponding 10ab from compounds 9ab, the three‐step reaction via deprotection, hydrogenolysis, and hydrogenation was carried out in a one‐pot procedure.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.