Silica Sulphuric Acid: An Efficient and Recyclable Catalyst for the Synthesis of β‐Acetamido Ketones in Single Pot

Abstract

An efficient method has been developed for the synthesis of β‐acetamido ketones by a multicomponent condensation route using sulphuric acid on silica gel as an inexpensive catalyst. Catalyst was recycled without loss of activity.

Keywords:

• Acetonitrile
• acetophenones
• acetyl chloride
• aromatic aldehydes
• silica sulphuric acid

Acknowledgments

The authors are thankful to J. S. Yadav, Director, IICT, and Sri S. Narayan Reddy, Head, Fluoroorganics, IICT, Hyderabad for constant encouragement and financial support from the industry‐sponsored project.