Efficient, Simple Preparation of 1,3‐Diamine Derivatives through Addition of Acrylamides with Secondary Amines

Yi Liu Department of Chemistry, Tsinghua University, Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing, China

Ruimao Hua Department of Chemistry, Tsinghua University, Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing, ChinaCorrespondence[email protected]

Xianqing Qiu Department of Chemistry, Tsinghua University, Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing, China

Abstract

Reaction of acrylamides with secondary amines results in the formation of β‐amino‐propionamide through the addition reaction of N–H bond of amines across the double bond of acrylamides in the good to excellent yield. The structure of 2‐methyl‐3‐(1‐piperidinyl)‐propionamide has been determined by X‐ray analysis.

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Acknowledgment

Financial support from Tsinghua University for scientific research is gratefully acknowledged.

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Efficient, Simple Preparation of 1,3‐Diamine Derivatives through Addition of Acrylamides with Secondary Amines

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Efficient, Simple Preparation of 1,3‐Diamine Derivatives through Addition of Acrylamides with Secondary Amines

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