Preparation of 1‐Arylideneamino‐ and 1‐Alkylideneamino‐3‐phenoxypropan‐2‐ol N‐Oxides—A New Type of Nitrones

Katarzyna Da˛bkowska Faculty of Chemistry, Warsaw University of Technology, Noakowskiego, Warsaw, Poland

Paulina Da˛browska Faculty of Chemistry, Warsaw University of Technology, Noakowskiego, Warsaw, Poland

Jacek Drabik Medical Research Center, Polish Academy of Sciences, Pawinskiego, Warsaw, Poland

Dorota Kopczuk Medical Research Center, Polish Academy of Sciences, Pawinskiego, Warsaw, Poland

Jan Plenkiewicz Faculty of Chemistry, Warsaw University of Technology, Noakowskiego, Warsaw, PolandCorrespondence[email protected]

Joanna B. Strosznajder Medical Research Center, Polish Academy of Sciences, Pawinskiego, Warsaw, Poland

Monika Wielechowska Faculty of Chemistry, Warsaw University of Technology, Noakowskiego, Warsaw, Poland

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Abstract

The reaction of phenylglycidyl ether with hydroxylamine was evaluated, and the prepared 1‐hydroxyamino‐3‐phenoxypropan‐2‐ol was used for the 1‐arylideneamino‐ and 1‐alkylideneamino‐3‐phenoxypropan‐2‐ol N‐oxides syntheses. The title nitrones were tested as antioxidants in biological systems.

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Preparation of 1‐Arylideneamino‐ and 1‐Alkylideneamino‐3‐phenoxypropan‐2‐ol N‐Oxides—A New Type of Nitrones

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Preparation of 1‐Arylideneamino‐ and 1‐Alkylideneamino‐3‐phenoxypropan‐2‐ol N‐Oxides—A New Type of Nitrones

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