Convenient Synthesis and Reactivity of Ethyl 8‐amino‐6‐methyl‐2,3‐dihydro‐4H‐1‐benzopyran‐2‐carboxylate

Abstract

We report and comprehensively describe the synthesis and reactivity of ethyl 8‐amino‐6‐methyl‐3,4‐dihydro‐2H‐1‐benzopyran‐2‐carboxylate. This peptidomimetic building block provides a constrained template that allows for the introduction of various functionalities in a specific spatial orientation.

Keywords:

• Benzopyranes
• 3,4‐dihydro‐2H‐1‐benzopyran derivatives
• reduction
• RGD mimetic

Acknowledgments

We thank Roger Pain for his careful reading of the manuscript and many useful suggestions.