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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 35, 2005 - Issue 11
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Original Articles

Microwave‐Assisted Protection of Phenols as tert‐Butyldimethylsilyl (TBDMS) Ethers Under Solvent‐Free Conditions

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Pages 1501-1509 | Received 27 Jan 2005, Published online: 17 Dec 2010
 

Abstract

A facile, time‐saving procedure to protect phenols with tert‐butyldimethylsilyl chloride using imidazole as catalyst under solvent‐free conditions is described. Several phenolic compounds with different substitution patterns can be silylated in high yield with substantially reduced generation of residues, a present goal in organic synthesis.

Acknowledgment

We thank Luiz Fernando da Silva Junior and Dieter Weiß for a critical reading of the manuscript and FAPESP (00/06652‐0, 01/07477‐0) and CAPES for substantial financial support.

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