Rapid and High‐Yield Synthesis of Aryloxyacetates Under Microwave Irradiation and Phase‐Transfer Catalysis Conditions

Abstract

A series of methyl aryloxyacetates (3a–3f) have been synthesized by the reaction of substituted phenol with methyl chloroacetate under the conditions of microwave irradiation and phase‐transfer catalysis. By the optimization of the reaction conditions, we developed a good method for the preparation of methyl aryloxyacetates, which have the advantages of high yields, short reaction times, ease of workup, and simple operation.

Keywords:

• Methyl aryloxyacetates
• microwave
• phase‐transfer catalyst

Acknowledgment

This work was supported by Natural Science Foundation (No. 20371040) of China, the Natural Science Foundation (No. 031‐A21‐004, 3ZS041‐A25‐007) of Gansu province, and the Foundation (No. 02‐18) of Northwest Normal University, which are gratefully acknowledged.