CuBr₂‐Catalyzed Synthesis of Bis(indolyl)methanes

Abstract

Copper(II) bromide is found to be an efficient catalyst for the electrophilic substitution reaction of indole with aldehydes to afford the corresponding bis(indolyl)methanes in good yields.

Keywords:

• Aldehydes
• bis(indolyl)methanes
• copper(II) bromide
• indole

Acknowledgment

The financial support for this work from Hebei Normal University and National Natural Science Foundation of China (20477009) is gratefully acknowledged.