Preparation of Methyl N‐Substituted Carbamates from Amides through N‐Chloroamides

Abstract

Amides are chlorinated on the nitrogen using trichloroisocyanuric acid, and the N‐chloroamides are then rearranged to the corresponding methyl N‐substituted carbamates by sodium methoxide in methanol.

Keywords:

• Amides
• N‐chloroamides
• methyl N‐substituted carbamates
• preparation
• rearrangement
• synthesis
• trichloroisocyanuric acid

Acknowledgment

This research was supported in part by a grant from the CSU Special Fund for Research, Scholarship, and Creative Activity.