Abstract
Synth. Commun. 2005, 35, 1983
Microwave‐Assisted Dehydration and Chlorination using Phosphonium Salt
Ken‐ichi Tanji, Jiro Koshio, and Osamu Sugimoto
Laboratory of Organic Chemistry, School of Food and Nutritional Sciences, University of Shizuoka, 52‐1 Yada, Shizuoka 422‐8526, Japan
Abstract
Synth. Commun. 2005, 35, 1989
Electrochemical Oxidation of Benzylic Amines into the Corresponding Imines in the Presence of Catalytic Amounts of KI
Mitsuhiro Okimoto, Yukio Takahashi, Kaori Numata, Yuji Nagata, and Gaku Sasaki
Department of Applied and Environmental Chemistry, Kitami Institute of Technology, Koen‐cyo 165, Kitami, 090‐8507 Japan
Several benzylic amines were transformed into the corresponding imines by indirect electrooxidation using iodide ion as an electron carrier.
Abstract
Synth. Commun. 2005, 35, 1997
CuBr2‐Catalyzed Synthesis of Bis(indolyl)methanes
Li‐Ping Mo, Zi‐Chuan Ma, and Zhan‐Hui Zhang
College of Chemistry, Hebei Normal University, Shijiazhuang, China
Copper(II) bromide is found to be an efficient catalyst for the electrophilic substitution reaction of indole with aldehydes to afford the corresponding bis(indolyl)methanes in good yields.
Abstract
Synth. Commun. 2005, 35, 2005
Improved and Highly Versatile Synthesis of 5‐Aryltropones
James Potenziano1, Robert Spitale2, and Mark E. Janik2
1Elan Pharmaceuticals Inc., 52 Overbrook Drive, Binghamton, NY 13901, USA
2Department of Chemistry, SUNY Fredonia, Fredonia, NY 14063, USA
The use of 5‐iodo‐2‐methoxytropone in palladium(0)‐catalyzed coupling reactions with a variety of arylboronic acids has resulted in significantly improved reactions yields and times for a sterically and electronically diverse of novel A‐ring modified 5‐aryltropones.
Abstract
Synth. Commun. 2005, 35, 2017
Solvent‐Free Synthesis of Arylamides and Arylimides, Analogues of Acetylcholine
J. Trujillo‐Ferrara1, José Correa‐Basurto1, Judith Espinosa1, Jazmín García1, Francisco Martínez2, and René Miranda3
1Seccion de Estudiós del Posgrado e investigación y Departmento de Bioquímica, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, México.
2Departamento de Química, Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Av. Acueducto s/n, Barrio Ticomán, México.
3Facultad de Estudios Superiores Cuautitlán, Departamento de Química, Universidad Nacional Autónoma de México, Mexico.
Various arylamides and arylimides related to acetylcholine were synthesizedunder solventless conditions. The target compounds were obtained with a good overall yield and with short reaction times.
Abstract
Synth. Commun. 2005, 35, 2025
Microwave‐Assisted Rapid Deacetalation of Carbohydrates
Mara Rubia C. Couri1, Erúzia A. Evangelista1, Rosemeire B. Alves1, Maria Auxiliadora F. Prado2, Rossimiriam P. F. Gil1, Mauro V. De Almeida3, and Délio S. Raslan1
1Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270‐901, Belo Horizonte, Brazil
2Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
3Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil
Abstract
Synth. Commun. 2005, 35, 2033
1,4‐Conjugate Additions of Methoxyamine and 1,1‐Dimethylhydrazine to Hex‐3‐yne‐2‐one: A Facile Synthesis of Functionalized Isoxazole and Pyrazole Precursors
Ronald R. Sauers and Susan D. Van Arnum
Department of Chemistry and Chemical Biology, Wright and Rieman Laboratories, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA
Abstract
Synth. Commun. 2005, 35, 2039
Synthesis of Symmetrical and Asymmetrical Phenethyl Thiourea Compounds as Nonnucleoside Inhibitors of HIV‐1 Reverse Transcriptase
T. K.Venkatachalam1, 2 and F. M. Uckun2, 3
1Department of Chemistry, Parker Hughes Institute, 2699 Patton Road, Roseville, Minnesota 55113, USA
2Drug Discovery Program, Parker Hughes Cancer Center, Roseville, Minnesota, USA
3Departments of Virology and Immunology, Parker Hughes Institute, Roseville, Minnesota, USA
Synthesis of symmetrical and asymmetrical phenethyl thioureas was accomplished in two steps with an overall yield of 75–80%. Condensation of a substitutedphenethyl amine with thiocarbonyldiimidazole, followed by treatment with one more equivalent of the phenethylamine in DMF, yielded the desired symmetrical phenethyl thiourea compound as a crystalline solid. In the case of asymmetrical thiourea derivatives, different amines were selected and condensed using a similar procedure. A series of 45 thiourea was synthesized.
Abstract
Synth. Commun. 2005, 35, 2057
Synthesis of an Oidiolactone Analogue from Abietic Acid
Paulo M. Imamura and Catarina dos Santos
Instituto de Química, Universidade Estadual de Campinas, UNICAMP C.P. 6154, 13084‐971, Campinas, São Paulo, Brazil
A synthesis of a new analogue of homosesquiterpene oidiolactone is described, starting from abietic acid.
Abstract
Synth. Commun. 2005, 35, 2067
Synthesis and Characterization of Alkyl and Aryl‐(4‐methyl‐6‐nitro‐quinolin‐2‐yl)amines: X‐Ray Structures of Ethyl and Cyclohexyl‐(4‐methyl‐6‐nitro‐quinolin‐2‐yl)amine
Melody R. Heiskell1, Martin D. Rudd2, Benjamin B. Penn3, and Jason A. Kautz4
1Louisiana Scholars' College, Northwestern State University, Natchitoches, LA 71497, USA
2Department of Chemistry, University of Wisconsin—Fox Valley, Menasha, WI 54952, USA
3Institute for Non Linear Optics, NASA Marshall Space Flight Center, Huntsville, AL 35812, USA
4Department of Chemistry and Biochemistry, Baylor University, Waco, TX 76798 USA
A three step synthesis starting from 4‐methylquinolin‐2‐ol has led to the isolation of alkyl and aryl‐(4‐Methyl‐6‐nitro‐quinolin‐2‐yl)amines. These have been characterized by multinuclear NMR spectroscopy and the structures of two examples have been determined by a single crystal X‐ray diffraction analysis.
Abstract
Synth. Commun. 2005, 35, 2079
CONVENIENT PREPARATION OF DIETHYL (2‐THIENYL)METHANEPHOSPHONATE
Matthew C. Davis
Chemistry & Materials Division (Code 498220D), Michelson Laboratory, Naval Air Warfare Center, China Lake, CA 93555, USA.
This paper describes a convenient preparation of the phosphonate 3 in 88% overall yield.
Abstract
Synth. Commun. 2005, 35, 2085
Convenient Preparation of N,N′‐Diphenyl‐N,N′‐bis(4‐aminophenyl)‐P‐phenylenediamine
Matthew C. Davis1, Andrew C. Chafin1, and Aaron J. Sathrum2
1Chemistry and Materials Division, Michelson Laboratory, Naval Air Warfare Center, China Lake, California, USA
2Engineer and Scientist Development Program (NAWCWD), Chemistry and Materials Division, Michelson Laboratory, Naval Air Warfare Center, China Lake, California, USA
This article describes modified conditions to prepare N,N′‐diphenyl‐N,N′‐bis(4‐aminophenyl)‐P‐phenylenediamine in 60% overall yield.
Abstract
Synth. Commun. 2005, 35, 2091
Preparation of Methyl N‐Substituted Carbamates from Amides through N‐Chloroamides
Gene A. Hiegel and Tyrone J. Hogenauer
Department of Chemistry and Biochemistry, California State University, Fullerton, California 92834, USA
Amides are chlorinated on the nitrogen using trichloroisocyanuric acid, and the N‐chloroamides are then rearranged to the corresponding methyl N‐subtituted carbamates by sodium methoxide in methanol.
Abstract
Synth. Commun. 2005, 35, 2099
Preparation of N‐Chloroamides using Trichloroisocyanuric Acid
Gene A. Hiegel, Tyrone J. Hogenauer, and Justin C. Lewis
Department of Chemistry and Biochemistry, California State University, Fullerton, California 92834, USA
Amides are efficiently converted to N‐chloroamides by trichloroisocyanuric acid (TCICA) in methanol.
Abstract
Synth. Commun. 2005, 35, 2107
Optimization of Chemo‐Enzymatic Epoxidation of Cyclohexene Mediated by Lipases
Marcelo Alves Moreira, Thiago Bergler Bitencourt, and Maria da Graça Nascimento
Departamento de Química, Universidade Federal de Santa Catarina – Florianópolis, SC, 88040‐970, Brazil
Lipases were used to generate peroxyoctanoic acid directly from octanoic acid and hydrogen peroxide and applied in situ in order to obtain cyclohexene oxide.