Synthesis, Characterization, and Biological Activity of Some Transition Metal Chelates of 4‐Acyloxime‐2‐pyrazolin‐5‐ones

Abstract

Chelates of chromium(III), cobalt(II), nickel(II) and copper(II) with 4‐formyloxime‐3‐phenyl‐1‐(2′,4′‐dinitrophenyl)‐2‐pyrazolin‐5‐one, 4‐acetyloxime‐3‐phenyl‐1‐(2′,4′‐dinitrophenyl)‐2‐pyrazolin‐5‐one and 4‐benzoyloxime‐3‐methyl‐1‐(2′,4′‐dinitrophenyl)‐2‐pyrazolin‐5‐one have been prepared and characterized on the basis of elemental analyses, conductivity, magnetic susceptibility measurements, spectral and thermal studies. All chelates are suggested to have an octahedral structure. Various ligand field parameters for the chromium(III), cobalt(II) and nickel(II) chelates have been calculated. All of the synthesized chelates have been screened for their biological activities against various microorganisms.

Acknowledgments

Financial assistance from the Government of Gujarat, Gandhinagar, is gratefully acknowledged. The authors are thankful to the Dahod Anaj Mahajan Sarvajanik Education Society, Dahod, the late Shri Girdharlal Sheth, Prof. Y. K. Agrawal, Professors J. R. Shah and R. M. Patel for generous help during this research. Thanks are also due to the Regional Sophisticated Instrumentation Centre, Lucknow for C, H, N analysis data, FT–IR, ¹³C NMR and FAB Mass spectral analyses, the Sophisticated Instrumentation Centre for Applied Research and Testing, Vidyanagar, for electronic spectral analyses, the Regional Sophisticated Instrumentation Centre, Nagpur, for thermogravimetric analyses.