Synthesis and Characterization of Metal Complexes of Acebutolol, Atenolol, and Propranolol Antihypertension Drugs

Abstract

The complexation of two transition metal ions with the β‐blocker drugs acebutolol (HL¹), atenolol (HL²), and propranolol (HL³) was studied in methanol and acetonitrile media at M:L (metal:ligand) molar ratio from 1:1 to 1:10. Cu(II) complexes with ligands having the stoichiometric ratio 1:4 (mononuclear copper(II) complexes) and 1:1 (binuclear copper(II) complexes) were prepared. The analytical data show that the metal to ligand ratio in the mononuclear Co(II) complexes was 1:2. The complexes were characterized on the basis of analytical data, magnetic moments, atomic absorption, infrared and electronic spectral data. Molar conductivities of the complexes at room temperature were measured. The conductivity values of the mononuclear Cu(II) complexes indicate weak electrolyte behavior, whereas the binuclear Cu(II) and mononuclear Co(II) complexes are non‐electrolytes. The thermal properties of all complexes have been studied by the DTA and TG.

Keywords:

• Metal complexes
• Molar conductivity
• Transition metal ion

Acknowledgments

The authors gratefully acknowledge the funding of this work by the Research Fund (Project No: 2001/2‐1) of Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey. They also greatly thank Prof. Dr. Nevzat Külcü and his assistants (University of Mersin, Faculty of Science and Arts, Department of Chemistry, Mersin, Turkey) for DTA‐TG analyses.