Synthesis, Spectral Studies, and Biological Activity of Metal Complexes of Benzofuran Thiosemicarbazides

Abstract

The complexes of Co(II), Cu(II), Ni(II), Cd(II), Hg(II), Zn(II), UO₂(VI), and Th(IV) with benzofuran thiosemicarbazides have been prepared. All complexes have the general formula MLX _n , where n = 2 or 4, X = Cl or NO₃ and L is the ligand prepared by the reaction of benzofuran‐2‐carboxyhydrazide with p‐methyl, p‐methoxy, or p‐bromophenylisothiocyanate. The complexes were characterized on the basis of elemental analyses, spectral, magnetic moment, and conductance studies. The ligands coordinate to the metal ions through the oxygen of the arbonyl group and the nitrogen of the hydrazine group. We have assigned the probable geometry for all of these complexes based on their physico‐chemical data. All the metal complexes and ligands were screened for their anti‐microbial activity.

Keywords:

• Metal complexes
• Spectral studies
• Biological activity
• Benzofuran thiosemicarbazides

Acknowledgments

One of the authors (MBH) is thankful to the University Grants Commission (UGC), New Delhi, for financial assistance in form of a Major Research Project and ZSQ is thankful to the UGC, New Delhi, for awarding a teacher fellowship under the IX plan period. We thank the Professor and Chairman, Department of Chemistry, Gulbarga University, Gulbarga, for encouragement and for the use of their facilities.