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Abstract
Three simple, rapid, and accurate techniques have been developed for the determination of chlordesmethyldiazepam. The first one depends on the spectrophotometric determination of the orange azodye resulting from the coupling of thymol with the acid induced hydrolysis product of chlordesmethyldiazepam after conversion to the corresponding diazonium salt. The second is the application of quantitative densitometry for the simultaneous determination of chlordesmethyldiazepam in the presence of its degradation product. While the third technique implies HPLC resolution efficiency in the determination of chlordesmethyldiazepam in the presence of its degradation product.
The validity of the proposed procedures were proved using the standard addition technique and laboratory prepared mixtures of the drug and its degradation product(s). The proposed procedures were successfully applied for the drug analysis in Tablet form.