Multifunctional nanoassemblies of block copolymers for future cancer therapy

Horacio CabralDivision of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo. 7-3-1 Hongo, Bunkyo-ku, Tokyo113-0033, Japan;Center for NanoBio Integration, The University of Tokyo. 7-3-1 Hongo, Bunkyo-ku, Tokyo113-8656, JapanCorrespondence[email protected]

Kazunori KataokaDivision of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo. 7-3-1 Hongo, Bunkyo-ku, Tokyo113-0033, Japan;Center for NanoBio Integration, The University of Tokyo. 7-3-1 Hongo, Bunkyo-ku, Tokyo113-8656, Japan;Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo. 7-3-1 Hongo, Bunkyo-ku, Tokyo113-8656, Japan;Department of Bioengineering, Graduate School of Engineering, The University of Tokyo. 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan

Abstract

Nanoassemblies from amphiphilic block copolymers are promising nanomedicine platforms for cancer diagnosis and therapy due to their relatively small size, high loading capacity of drugs, controlled drug release, in vivo stability and prolonged blood circulation. Recent clinical trials with self-assembled polymeric micelles incorporating anticancer drugs have shown improved antitumor activity and decreased side effects encouraging the further development of nanoassemblies for drug delivery. This review summarizes recent approaches considering stimuli-responsive, multifunctionality and more advanced architectures, such as vesicles or worm-like micelles, for tumor-specific drug and gene delivery.

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Multifunctional nanoassemblies of block copolymers for future cancer therapy

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Multifunctional nanoassemblies of block copolymers for future cancer therapy

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