![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
We have prepared multifunctional magnetic mesoporous Fe–CaSiO3 materials using triblock copolymer (P123) as a structure-directing agent. The effects of Fe substitution on the mesoporous structure, in vitro bioactivity, magnetic heating ability and drug delivery property of mesoporous CaSiO3 materials were investigated. Mesoporous Fe–CaSiO3 materials had similar mesoporous channels (5–6 nm) with different Fe substitution. When 5 and 10% Fe were substituted for Ca in mesoporous CaSiO3 materials, mesoporous Fe–CaSiO3 materials still showed good apatite-formation ability and had no cytotoxic effect on osteoblast-like MC3T3-E1 cells evaluated by the elution cell culture assay. On the other hand, mesoporous Fe–CaSiO3 materials could generate heat to raise the temperature of the surrounding environment in an alternating magnetic field due to their superparamagnetic property. When we use gentamicin (GS) as a model drug, mesoporous Fe–CaSiO3 materials release GS in a sustained manner. Therefore, magnetic mesoporous Fe–CaSiO3 materials would be a promising multifunctional platform with bone regeneration, local drug delivery and magnetic hyperthermia.
Acknowledgments
The authors gratefully acknowledge the support by the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, National Natural Science Foundation of China (no. 51102166), Program for New Century Excellent Talent in University (no. NCET-12-1053), Key Project of Chinese Ministry of Education (no. 212055), Shanghai Pujiang Program (no. 11PJ1407300), Shanghai Shuguang Project (no. 12SG39) and Innovation Program of Shanghai Municipal Education Commission (no. 12ZZ140).
Notes
4 ISO/EN 10993-5. Biological evaluation of medical devices—part 5 tests for cytotoxicity, in vitro methods: 8.2 tests on extracts.