Structure of Germ Line Immunoglobulin α Heavy-Chain RNA and Its Location on Polysomes

Gail Radcliffe1 Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts01655

Yi-Chaung Lin1 Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts01655

Martin Julius2 Department of Biochemistry, State University of New York, Stony Brook, New York11733-5215

Kenneth B. Marcu2 Department of Biochemistry, State University of New York, Stony Brook, New York11733-5215

Janet Stavnezer1 Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts01655

Abstract

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin α heavy-chain genes in immunoglobulin M-expressing cells of the I.29μ B-cell lymphoma, a cell line capable of switching to immunoglobulin A expression upon lipopolysaccharide treatment. This germ line α RNA has a small open reading frame that does not include the Cα domain, and this RNA appears to be present on polysomes in I.29μ cells.

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Structure of Germ Line Immunoglobulin α Heavy-Chain RNA and Its Location on Polysomes

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Structure of Germ Line Immunoglobulin α Heavy-Chain RNA and Its Location on Polysomes

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