Tst-1, a Member of the POU Domain Gene Family, Binds the Promoter of the Gene Encoding the Cell Surface Adhesion Molecule Po

Xi He1 Eukaryotic Regulatory Biology Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, California92093-0648;2 Center for Molecular Genetics, and Departments of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California92093-0648

Renee Gerrero1 Eukaryotic Regulatory Biology Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, California92093-0648;3 Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California92093-0648

Donna M. Simmons4 Neural Systems Laboratory, The Salk Institute, La Jolla, California92037

Ronald E. Park1 Eukaryotic Regulatory Biology Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, California92093-0648

Chijen R. Lin1 Eukaryotic Regulatory Biology Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, California92093-0648

Larry W. Swanson4 Neural Systems Laboratory, The Salk Institute, La Jolla, California92037;5 Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, La Jolla, California92093-0648

Michael G. Rosenfeld1 Eukaryotic Regulatory Biology Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, California92093-0648;5 Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, La Jolla, California92093-0648

show all

Abstract

Tst-1, a member of the POU domain gene family, is expressed in specific neurons and in myelinating glia in the mammalian nervous system. Bacterially expressed Tst-1 binds specifically to the promoter of the gene encoding myelin protein Po, a Schwann cell surface adhesion molecule. In cotransfection assays, Tst-1 can specifically repress the Po promoter. The N-terminal part of Tst-1 protein is highly glycine- and alanine-rich, a structural feature shared by the helix-loop-helix protein TFEB.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Tst-1, a Member of the POU Domain Gene Family, Binds the Promoter of the Gene Encoding the Cell Surface Adhesion Molecule Po

Information for

Open access

Opportunities

Help and information

Tst-1, a Member of the POU Domain Gene Family, Binds the Promoter of the Gene Encoding the Cell Surface Adhesion Molecule Po

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature