Adenovirus Type 5 E1A Gene Products Act as Transformation Suppressors of the neu Oncogene

Abstract

The adenovirus type 5 early region 1A (E1A) gene was introduced into neu-transformed B104-1-1 cells. Cells that expressed El A possessed reduced transforming activity in vitro and reduced tumorigenicity in nude mice. These results demonstrate that the E1A gene products can act negatively to suppress the transformed phenotype in new-transformed cells.