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Molecular and Cellular Biology Volume 2, 1982 - Issue 10
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Adenovirus Type 5 Induces Progression of Quiescent Rat Cells into S Phase Without Polyamine Accumulation

B. F. CheethamDepartment of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T. 2601, Australia
,
D. C. ShawDepartment Physical Biochemistry, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T. 2601, Australia
&
A. J. D. BellettDepartment of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T. 2601, Australia
Pages 1295-1298 | Received 05 Apr 1982, Accepted 08 Jun 1982, Published online: 31 Mar 2023
 
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Abstract

Adenovirus type 5 induces cellular DNA synthesis and thymidine kinase in quiescent rat cells but does not induce ornithine decarboxylase. We now show that unlike serum, adenovirus type 5 fails to induce S-adenosylmethionine decarboxylase or polyamine accumulation. The inhibition by methylglyoxal bis(guanylhydrazone) of the induction of thymidine kinase by adenovirus type 5 is probably unrelated to its effects on polyamine biosynthesis. Thus, induction of cellular thymidine kinase and DNA replication by adenovirus type 5 is uncoupled from polyamine accumulation.

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