Transcription of the Mouse Dihydrofolate Reductase Gene Proceeds Unabated Through Seven Polyadenylation Sites and Terminates Near a Region of Repeated DNA

Elizabeth G. FrayneVerna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas77030

Eugene J. LeysVerna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas77030

Gray F. CrouseNational Cancer Institute, Frederick, Maryland21701

Amy G. HookVerna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas77030

Rodney E. KellemsVerna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas77030

Abstract

We observed equimolar transcription throughout the 35-kilobase mouse dihydrofolate reductase structural gene. Transcription termination occurred within a discrete region (900 base pairs) located 1 kilobase beyond the last of seven functional polyadenylation sites and near a repetitive DNA sequence element. The results imply that a distinct genetic signal may be associated with the process of transcription termination.

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Transcription of the Mouse Dihydrofolate Reductase Gene Proceeds Unabated Through Seven Polyadenylation Sites and Terminates Near a Region of Repeated DNA

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Transcription of the Mouse Dihydrofolate Reductase Gene Proceeds Unabated Through Seven Polyadenylation Sites and Terminates Near a Region of Repeated DNA

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