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Research Article

Heat-Inducible Human Factor That Binds to a Human hsp70 Promoter

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Pages 1530-1534 | Received 03 Sep 1986, Accepted 18 Dec 1986, Published online: 31 Mar 2023
 

Abstract

A factor found in nuclear extracts of human cells bound to the heat shock element of a human heat shock protein 70 gene. The level of this factor was significantly increased after heat shock. This induction was rapid and was not blocked by cycloheximide, suggesting that an initial event in the response of a human cell to heat is the activation of a preexisting regulatory factor.

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