Developmental Expression of Two Forms of pp60^c-src in Mouse Brain

Abstract

The expression during mouse development of two forms of protein-tyrosine kinase pp60^c-src, pp60 and pp60⁺, was investigated. At embryonic day 9 (E9), only pp60 was detected in whole-brain lysates. A trace of pp60⁺ was first seen at E10. In E18 embryos and in adults, pp60⁺ was the predominant form of pp60^c-src in forebrain and midbrain lysates.