B-raf, a New Member of the raf Family, is Activated by DNA Rearrangement

Shuntaro Ikawa1 Department of Oncology, Institiate of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-kia, Tokyo, Japan

Mikiharu Fukui1 Department of Oncology, Institiate of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-kia, Tokyo, Japan

Yoshito Ueyama2 Department of Pathology, School of Medicine, Tokai University, 259-11 Bouseidai, Isehara-shi, Kanagawa, Japan

Norikazu Tamaoki2 Department of Pathology, School of Medicine, Tokai University, 259-11 Bouseidai, Isehara-shi, Kanagawa, Japan

Tadashi Yamamoto1 Department of Oncology, Institiate of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-kia, Tokyo, Japan

Kumao Toyoshima1 Department of Oncology, Institiate of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-kia, Tokyo, Japan

Abstract

Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.

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B-raf, a New Member of the raf Family, is Activated by DNA Rearrangement

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B-raf, a New Member of the raf Family, is Activated by DNA Rearrangement

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