Mapping of Cellular Protein-Binding Sites on the Products of Early-Region 1A of Human Adenovirus Type 5

Cay Egan1 Departments of Biology, McMaster University, Hamilton, Ontario, CanadaL8N 3Z5;2 Molecular Virology and Immunology Program, McMaster University, Hamilton, Ontario, CanadaL8N 3Z5

Tony N. Jelsma1 Departments of Biology, McMaster University, Hamilton, Ontario, CanadaL8N 3Z5

John A. Howe1 Departments of Biology, McMaster University, Hamilton, Ontario, CanadaL8N 3Z5

Stanley T. Bayley1 Departments of Biology, McMaster University, Hamilton, Ontario, CanadaL8N 3Z5

Blair Ferguson3 Experimental Station, E. I. du Pont de Nemours & Co., Inc., Wilmington, Delaware19898

Philip E. Branton2 Molecular Virology and Immunology Program, McMaster University, Hamilton, Ontario, CanadaL8N 3Z5;4 Pathology, McMaster University, Hamilton, Ontario, CanadaL8N 3Z5

Abstract

The binding sites for the 300-, 107-, and 105-kilodalton cellular proteins which associate with human adenovirus type 5 E1A products were studied with E1A deletion mutants. All appeared to bind to the amino-terminal half of E1A products in regions necessary for oncogenic transformation. These results suggest that these cellular species may be important for the biological activity of E1A products.

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Mapping of Cellular Protein-Binding Sites on the Products of Early-Region 1A of Human Adenovirus Type 5

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Mapping of Cellular Protein-Binding Sites on the Products of Early-Region 1A of Human Adenovirus Type 5

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