Sequence and Structure of the Drosophila melanogaster Ovarian Tumor Gene and Generation of an Antibody Specific for the Ovarian Tumor Protein

Abstract

Sequencing cDNA and genomic DNA from the ovarian tumor gene revealed a gene with seven introns spanning 4.5 kilobases. The proline-rich, hydrophilic otu protein is novel. An antibody prepared to a β-gal-otu fusion protein recognized a 110-kilodalton ovarian protein which was altered in the ovaries of otu gene mutants.