The Alternatively Spliced Exon of the Platelet-Derived Growth Factor A Chain Encodes a Nuclear Targeting Signal

David W. Maher1 Departments of Chemistry, University of California—San Diego, La Jolla, California92093;2 Center for Molecular Genetics, University of California—San Diego, La Jolla, California92093

Bruce A. Lee2 Center for Molecular Genetics, University of California—San Diego, La Jolla, California92093;3 Biology, University of California—San Diego, La Jolla, California92093

Daniel J. Donoghue1 Departments of Chemistry, University of California—San Diego, La Jolla, California92093;2 Center for Molecular Genetics, University of California—San Diego, La Jolla, California92093

Abstract

We have previously shown that the SIS/platelet-derived growth factor B chain contains a nuclear targeting signal near its C terminus. Here we show that the platelet-derived growth factor A chain also contains a nuclear targeting signal encoded by an exon which is subject to alternative splicing. This sequence is capable of targeting a nonsecreted form of the A chain to the nucleus and can also target the cytoplasmic proteins dihydrofolate reductase, chloramphenicol acetyltransferase, and pyruvate kinase to the nucleus.

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The Alternatively Spliced Exon of the Platelet-Derived Growth Factor A Chain Encodes a Nuclear Targeting Signal

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The Alternatively Spliced Exon of the Platelet-Derived Growth Factor A Chain Encodes a Nuclear Targeting Signal

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