Regulation of Tissue Factor Gene Expression in the Monocyte Procoagulant Response to Endotoxin†

Abstract

Tissue factor is the cellular receptor and cofactor for plasma factor Vila which initiates the coagulation protease cascade on cell surfaces. Although normally absent from all intravascular cell types, tissue factor can be induced to appear on circulating monocytes and vascular endothelial cells by specific inflammatory or immunological mediators. In this study, we have examined the regulation of endotoxin-induced tissue factor gene expression in peripheral blood monocytes.