![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
The mouse myelin basic protein promoter was transcribed in brain nuclear extracts. The distal promoter region from ‒253 to ‒54 directed preferential transcription in brain extracts, whereas the same region repressed transcription activity in liver extracts. Stimulation of transcription was observed when the distal region was located only in a native orientation. The proximal region downstream from ‒53 alone still directed preferential transcription. It is suggested that cooperative function by the two promoter regions may be required for higher specificity.