A Review of Electrostatic Measurement Techniques for Aerosol Drug Delivery to the Lung: Implications in Aerosol Particle Deposition

Abstract

Electrostatic properties of formulation components play an important role in inhalation products. Suitable measurement of charge distribution will, therefore, lead to better control of inhalation formulation manufacture. Advances in this field have been made in the past few years but, real time, direct techniques still need to be developed further to obtain a precise, accurate and easy to use measurement of electrically charged aerosolised powders. This short review presents an overview of the various techniques present in literature for measurement of charge applicable to inhalation dosage forms.

Keywords:

• PHARMACEUTICAL AEROSOLS
• ELECTROSTATIC CHARGE
• FARADAY PAIL
• ELPI
• E-SPART
• PDA
• ENGI