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Journal of Biomaterials Science, Polymer Edition Volume 20, 2009 - Issue 7-8
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Articles

Temperature-Sensitive Biodegradable Poly(ethylene glycol)

Jisun Lee Department of Chemistry, Division of Nano Sciences, Ewha Womans University, Seoul 120-750, South Korea
,
Min Kyung Joo Department of Chemistry, Division of Nano Sciences, Ewha Womans University, Seoul 120-750, South Korea
,
Jinheung Kim Department of Chemistry, Division of Nano Sciences, Ewha Womans University, Seoul 120-750, South Korea
,
Jong Sang Park Department of Chemistry, Seoul National University, Seoul, South Korea
,
Moon-Young Yoon Department of Chemistry, Hanyang University, Seoul, South Korea
&
Byeongmoon Jeong Department of Chemistry, Division of Nano Sciences, Ewha Womans University, Seoul 120-750, South Korea
Pages 957-965 | Published online: 02 Apr 2012
 
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Abstract

We report here that the incorporation of several disulfide bonds along poly(ethylene glycol) (PEG) gives temperature sensitivity, as well as biodegradability to PEG. To synthesize a PEG with temperature sensitivity in a physiologically important range (20–40°C), PEGs with molecular masses of 400 and 600 Da were randomly coupled by disulfide bonds. As the mol ratio of PEG (400 Da) disulfide to PEG (600 Da) disulfide increased from 40:60 to 60:40, the cloud point of the polymer aqueous solution decreased from 35°C to 27°C. The disulfide bonds between PEGs were degraded in the presence of a thiol-containing biomolecule of glutathione in a thiol-concentration-dependent manner.

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