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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 26, 2004 - Issue 2
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Articles

Peripheral nerve regeneration through guidance tubes

Jason S. BelkasDivision of Neurosurgery and Neuroscience Research ProgramSunnybrook & Women's College Health Sciences Centre, University of Toronto
,
Molly S. ShoichetDepartment of Chemical Engineering and Applied Chemistry and Department of ChemistryInstitute of Biomaterials and Biomedical Engineering, University of Toronto
&
Rajiv MidhaDivision of Neurosurgery and Neuroscience Research ProgramSunnybrook & Women's College Health Sciences Centre, University of Toronto
Pages 151-160 | Published online: 19 Jul 2013
 
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Abstract

Biological nerve grafts have been extensively utilized in the past to repair peripheral nerve injuries. More recently,the use of synthetic guidance tubes in repairing these injuries has gained in popularity.This review focuses on artificial conduits, nerve regeneration through them, and an account of various synthetic materials that comprise these tubes in experimental animal and clinical trials. It also lists and describes several biomaterial considerations one should regard when designing, developing, and manufacturing potential guidance channel candidates. In the future, it it likely that the most successful synthetic nerve conduit will be one that has been fabricated with some of these strategies in mind.

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