An update on disordered iron metabolism and iron overload

Abstract

Iron overload is a major cause of morbidity and mortality in transfusion-dependent anemias. Greater understanding of the mechanisms of iron regulation and the role of toxic iron moieties and their predilection for certain organs has enhanced our ability to better target therapies in recent years, as illustrated by the Thalassemia syndromes.

Keywords:

• IRON OVERLOAD
• THALASSEMIA
• HEPCIDIN
• IRON CHELATION