The Role of Anthropometric Characteristics (Weight, Body Fat) on Pain Perception Threshold

Abstract

Pain threshold has become an attractive semi-objective measure of sensitivity. Despite its popularity, a number of factors may affect pain threshold measurement. Previous studies have mainly concentrated on factors such as age, gender, blood pressure and menstrual cycle. Few data exist in relation to the potential effect of anthropometric characteristics and especially of body fat and weight on pain threshold. This review aims to present current data in relation to body fat estimates and pain threshold and to stimulate further research to delineate the issue. Reviewed data are separately presented for animal models, experimental human studies, and clinical paradigms. The majority of presented data suggest that pain threshold seems to be inversely related to body fat estimates, both for animal and human models. Preliminary clinical studies support this suggestion. Possible explanations are discussed. Further research is warranted to confirm the findings.