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Redox Report
Communications in Free Radical Research
Volume 8, 2003 - Issue 5
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Articles

Haemoglobinopathies and resistance to malaria

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Pages 304-310 | Published online: 19 Jul 2013
 

Abstract

The haemoglobinopathies have a celebrated role in the study of human genetics as the first examples of balanced polymorphisms described in human populations. Over the last 50 years, considerable evidence has been provided to show that these traits do confer protection from malaria. More recently, the underlying mechanisms of protection have been examined. This short review summarizes these studies and where possible shows how the putative mechanisms of protection may be linked to redox processes.

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