Antioxidant activity of new ruthenium compounds

Marcos Marques da Silva PaulaLaboratório de Síntese de Complexos Multifuncionais, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil

Claus Tröger PichLaboratório de Síntese de Complexos Multifuncionais, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil

Fabrícia PetronilhoLaboratório de Fisiopatologia Experimental, UNESC, SC, Brazil

Lilian Batista DreiLaboratório de Síntese de Complexos Multifuncionais, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil

Martina RudnickiCentro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

Marcos Roberto de OliveiraCentro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

José Cláudio Fonseca MoreiraCentro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

João Antônio Pegas HenriquesCentro de Biotecnologia, UFRGS, Porto Alegre, RS, Brazil; Curso de Farmácia, Universidade Luterana do Brasil, Canos, RS, Brazil

César Vittorio FrancoDepartamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil

Felipe Dal PizzolCentro de Estudos em Estresse Oxidativo, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Laboratório de Fisiopatologia Experimental, UNESC, SC, Brazil

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Abstract

Many biological properties have been attributed to ruthenium complexes including anti-tumor activity and the attenuation of reperfusion damage and infarct size. In this work, we characterize the antioxidant activity of trans-[RuCl₂(nic)₄] where nic is 3-pyridinecarboxylic acid and trans-[RuCl₂(i-nic)₄] where i-nic is 4-pyridinecarboxylic acid by (i) evaluation of total antioxidant potential (TRAP); (ii) prevention of DNA damage induced by hydrogen peroxide using the alkaline comet assay; and (iii) the prevention of lipid peroxidation and cell death induced by iron in liver slices. Our results suggest that nic has stronger antioxidant potential when compared to the i-nic. Higher doses (above 200 μM) of these compounds gave genotoxic effects, but the antioxidant potential could be obtained with the use lower doses (0.1–10 μM).

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Antioxidant activity of new ruthenium compounds

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Antioxidant activity of new ruthenium compounds

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