Acute exercise increases expression of extracellular superoxide dismutase in skeletal muscle and the aorta

Yoshiaki HitomiDepartment of Molecular Predictive Medicine and Sport ScienceSchool of Medicine, Kyorin University, Mitaka, Tokyo, Japan; Department of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan

Sumiko WatanabeDepartment of Molecular Predictive Medicine and Sport ScienceSchool of Medicine, Kyorin University, Mitaka, Tokyo, Japan

Takako KizakiDepartment of Molecular Predictive Medicine and Sport ScienceSchool of Medicine, Kyorin University, Mitaka, Tokyo, Japan

Takuya SakuraiDepartment of Molecular Predictive Medicine and Sport ScienceSchool of Medicine, Kyorin University, Mitaka, Tokyo, Japan

Tohru TakemasaInstitute of Health and Sport SciencesUniversity of Tsukuba, Tsukuba, Ibaraki, Japan

Shukoh HagaInstitute of Health and Sport SciencesUniversity of Tsukuba, Tsukuba, Ibaraki, Japan

Tomomi OokawaraDepartment of BiochemistryHyogo College of Medicine, Nishinomiya, Hyogo, Japan

Keiichiro SuzukiDepartment of BiochemistryHyogo College of Medicine, Nishinomiya, Hyogo, Japan

Hideki OhnoDepartment of Molecular Predictive Medicine and Sport ScienceSchool of Medicine, Kyorin University, Mitaka, Tokyo, Japan

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Abstract

Exercise dramatically increases oxygen consumption and causes oxidative stress. Superoxide dismutase (SOD) is important in the first-line defence mechanisms against oxidative stress. To investigate the effect of acute exercise on the expression of SOD, we examined the expression of mRNA for three SOD isozymes, in mice run on a treadmill to exhaustion. Six hours after exercise, the expression of extracellular SOD (EC-SOD) mRNA increased significantly in skeletal muscle and persisted for 24 h, whereas no change was observed for cytoplasmic and mitochondrial SOD mRNA. Moreover, acute exercise also induced EC-SOD mRNA in the aorta. These results suggest that a single bout of exercise is enough to augment the expression EC-SOD mRNA in skeletal muscle and the aorta, and may partly explain the beneficial effect of exercise.

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Acute exercise increases expression of extracellular superoxide dismutase in skeletal muscle and the aorta

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Acute exercise increases expression of extracellular superoxide dismutase in skeletal muscle and the aorta

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