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Abstract
Spinocerebellar ataxia type 2 (SCA2) is a redox-sensitive neurodegenerative disease affecting the cerebellum, fibre connections in the cerebellum, the peripheral nervous system, and extracerebellar central pathways. Currently, Cuba has the highest reported global rate for this disease. The aim of this review article is to summarize and discuss the current knowledge about evidence of oxidative stress during SCA2. Recent reports have suggested that ataxin 2 and other related factors contribute to the redox imbalance in this disease. It is important to recognize and clarify the molecular mechanisms associated with the redox imbalance to consider ataxias innovative approaches to counteract oxidative stress-induced tissue damage, through alternative therapeutic or nutritional intervention in SCA2 and related diseases.
Acknowledgements
This work was partially supported by the Ministry of Science, Technology and Environment of the Republic of Cuba (Project CITMA No. 070811). Special thanks to all the researchers of the Center for the Research and Rehabilitation of Hereditary Ataxias ‘Carlos J. Finlay’ Holguín, Cuba who kindly contributed to this work. We are indebted to Dr Melba C. Jaramillo for her critical review and corrections.