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Abstract
Objectives: Paraoxonase-1 (PON1) prevents oxidative stress by inhibiting the oxidation of cell membrane lipids by the reactive oxygen species that form during acute and chronic inflammation. The aim of this study was to investigate serum PON1 activity and oxidative stress in patients with chronic otitis media (COM).
Methods: Fifty consecutive patients with COM and 55 controls were enrolled in the present study. The patients were divided into two groups according to the presence of cholesteatoma. The serum PON1 arylesterase activities and lipid hydroperoxide (LOOH) levels were determined.
Results: Serum paraoxonase and arylesterase activities were significantly lower in the COM patients than in the controls (P < 0.001 for all comparisons), whereas the LOOH levels were significantly higher (P < 0.001).
Discussion: These results indicated that a lower level of PON1 activity was associated with an oxidant–antioxidant imbalance. In addition, decreased PON1 activity may play an important role in the pathophysiology of COM.
Disclaimer statements
Contributors Conception and design: MT, RU, MA, and HC; analysis and interpretation of the data: MT, FK, and AT; critical revision of the article for important intellectual content: MT, RU, and MFG; final approval of the article: MT, RU, and MA; collection and assembly of data: MT, MA, and MFG.
Funding None.
Conflicts of interest None.
Ethics approval Yes.