Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation Joo H, Lin Z, Arnold FH. Nature 1999; 399: 670–673

Abstract

The article entitled Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylations, by Hyun Joo, Zhanglin Lin and Francis H. Arnold of the Division of Chemistry and Chemical Engineering, California Institute of Technology, recently communicated in Nature,¹ is an excellent example of the revolution in the biological sciences. We frequently hear that we are in the midst of an informational revolution. If one simply considers the fact that all biological information exists in DNA, it is possible to envision the biological informational revolution. Alternatively, the term technological revolution is applied to the many recent advances in several fields, including the biological sciences. Both the informational and technological revolution can be readily recognized in the article by Joo and colleagues.