Development and application of cetirizine hydrochloride drug sensor

Abstract

A cetirizine hydrochloride polyvinyl chloride (PVC) membrane drug sensor was developed by using an ion association complex generated with sodium tetraphenylborate and cetirizine hydrochloride as an electroactive substance. In a sodium dihydrogen phosphate–sodium hydroxide buffer solution of pH 5·0, the linear range of the sensor was 1·58 × 10⁻⁶ − 1·0 × 10⁻¹ M, the slope was 46 mV pC⁻¹ at 20°, the detection limit was 6·31 × 10⁻⁷ M, and the response time was less than 10 seconds. The sensor has excellent reproducibility with the relative standard deviation of its potential value less than 5%. When the sensor was used to determine cetirizine hydrochloride in drugs, the relative standard deviation was less than 3%. Moreover, the results were consistent with the labeled content in preparations.

Keywords:

• Cetirizine hydrochloride
• PVC membrane sensor
• Development
• Application